Hansen Solubility Parameters (HSP)

Smart and efficient ingredient matching

  • Fast, practical and accurate HSP determinations
  • Implementation of HSP in formulations
  • Match or replace ingredients
  • Improve solubility, compatibility, stability and efficacy

How it works

Together with Prof. Steven Abbott and Dr. Charles Hansen, VLCI promotes HSP for a wide range of applications.

HSP Principle

Solubility of a product is represented as a sphere and characterized by three Hansen Solubility Parameters (HSP):  

  • δD for Dispersion (van der Waals)
  • δP for Polarity (Dipole Moment)
  • δH for Hydrogen Bonding

The HSP theory is based on the “like seeks like” principle, with likeness measured by the HSP distance metric. The critical conditions for solubility are found within a spherical region of HSP space, around the centre. Therefore, inclusions in the sphere, or overlapping spheres, predict solubility or compatibility.

HSP determination is a powerful and practical way to understand, predict and improve:

  • Solubility
  • Compatibility
  • Stability
  • Efficacy

HSPs allow strong predictions for smart and efficient ingredient matching, and is applicable to many types of ingredients: polymers, oils, pigments, solvents, additives…

Our Expertise

VLCI is a certified research centre for determinations of HSP and implementations thereof. The solubility (or dispersibility) of a product is assessed within a standardized set of solvents with known HSPs, spread over the 3-dimensional HSP space. Solvents and products are automatically dispensed via the gravimetric dispensing unit of our High Throughput platform. The solubility is ranked from 1 (excellent) to 6 (very poor). Based on these scores, the HSPiP software generates the solubility sphere of the tested product.

Read  Also

How to Predict Efficient Active Delivery in Cosmetics Using HSP

Determining Solubility of Nail Varnishes via HSP

Practical Determination and Application of HSP for the Paints & Coatings Industry

HSP-Based Dispersants Selection Method for Instant Match

Let us know how we can help

  • This field is for validation purposes and should be left unchanged.

Applications & Project Examples

  • Solvents outside the solubility sphere of a product can be blended to reach HSP’s within the sphere. By this means, toxic or environmentally unsustainable solvents can be replaced by blends of non-hazardous and/or bio-based solvents.
  • Dispersants can be matched with specific solid particles for the preparation of optimally stabilized suspensions.
  • Film formation of acrylic dispersions can be enhanced via the effective selection of coalescing agents.
  • Solubility of pharmaceutical actives can be significantly improved.

VLCI offers HSP expertise combined with High Throughput capabilities to deliver fast, practical and accurate results.