Hansen Solubility Parameters (HSP)

Smart and efficient ingredient matching

  • Fast, practical and accurate HSP determinations
  • Implementation of HSP in formulations
  • Match or replace ingredients
  • Improve solubility, compatibility, stability and efficacy

How it works

“Together with Prof. Steven Abbott and Dr. Charles Hansen, VLCI promotes HSP for a wide range of applications.”

HSP Principle

Solubility of a product is represented as a sphere and characterized by three Hansen Solubility Parameters (HSP):  

  • δD for Dispersion (van der Waals)
  • δP for Polarity (Dipole Moment)
  • δH for Hydrogen Bonding

The HSP theory is based on the “like seeks like” principle, with likeness measured by the HSP distance metric. The critical conditions for solubility are found within a spherical region of HSP space, around the centre. Therefore, inclusions in the sphere, or overlapping spheres, predict solubility or compatibility.

HSP determination is a powerful and practical way to understand, predict and improve:

  • Solubility
  • Compatibility
  • Stability
  • Efficacy

HSPs allow strong predictions for smart and efficient ingredient matching.

Our Expertise

The solubility (or dispersibility) of a product is assessed within a standardized set of solvents with known HSPs, spread over the 3-dimensional HSP space. Solvents and products are automatically dispensed via the gravimetric dispensing unit of our High Throughput platform. The solubility is ranked from 1 (excellent) to 6 (very poor). Based on these scores, the HSPiP software generates the solubility sphere of the tested product.

Let us know how we can help

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Applications & Project Examples

  • Solvents outside the solubility sphere of a product can be blended to reach HSP’s within the sphere. By this means, toxic or environmentally unsustainable solvents can be replaced by blends of non-hazardous and/or bio-based solvents.
  • Dispersants can be matched with specific solid particles for the preparation of optimally stabilized suspensions.
  • Film formation of acrylic dispersions can be enhanced via the effective selection of coalescing agents.
  • Solubility of pharmaceutical actives can be significantly improved.

VLCI offers HSP expertise combined with High Throughput capabilities to deliver fast, practical and accurate results.